Check,Publication.year,Fish,Habitat,Environment,Fish.Species,Fish.Family,Thermal.minimum,Thermal.max,Thermal.range,Thermal.tolerance,Fish.details,Fish.age,Fish.sex,Study.type,Control.temp,Thermal.D.control,Test.temp,D.Test.temp,Test.Cont.D,Thermal.D.test,Test.D.Tmin,Test.D.Tmax,Test.D.min,Exposure.exp.temp,Method,Specific.method,Immune.cells.studied,Category.Studied,Studied,Fold.change,Direction.change,Challenge.category,Challenge,Pathogen.challenge,Author.country,Fish.source,Average.N.group,Experiment.repeated,Paper,ID,Temperature.exposure,Immunogen.exposure,Reference,Notes,David.Zebra,Ensembl.Zebra,Ensembl.Rainbow,Fish.identifier,Human.homolog,PANTHER.protein,CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM,SIGNALING_BY_INTERLEUKINS,INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING,IMMUNE_SYSTEM,INNATE_IMMUNE_SYSTEM,SARS_COV_2_ACTIVATES_MODULATES_INNATE_AND_ADAPTIVE_IMMUNE_RESPONSES,CYTOKINE_SIGNALING_IN_IMMUNE_SYSTEM.1,INTERFERON_ALPHA_BETA_SIGNALING,INNATE_IMMUNE_SYSTEM.1,INFECTIOUS_DISEASE,SARS_COV_INFECTIONS,TOLL_LIKE_RECEPTOR_CASCADES,SARS_COV_2_HOST_INTERACTIONS,SIGNALING_BY_INTERLEUKINS.1,INTERLEUKIN_10_SIGNALING,SARS_COV_2_INFECTION,INTERFERON_SIGNALING,DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA,INTERLEUKIN_6_SIGNALING,TOLL_LIKE_RECEPTOR_CASCADES.1,INTERLEUKIN_6_FAMILY_SIGNALING,INTERFERON_SIGNALING.1,TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE,DISEASES_OF_IMMUNE_SYSTEM,INTERLEUKIN_1_FAMILY_SIGNALING,TOLL_LIKE_RECEPTOR_TLR1_TLR2_CASCADE,INTERLEUKIN_6_SIGNALING.1,INTERFERON_GAMMA_SIGNALING,INTERLEUKIN_6_FAMILY_SIGNALING.1,SARS_COV_1_ACTIVATES_MODULATES_INNATE_IMMUNE_RESPONSES,GROWTH_HORMONE_RECEPTOR_SIGNALING,REGULATION_OF_IFNA_IFNB_SIGNALING,INTERLEUKIN_4_AND_INTERLEUKIN_13_SIGNALING.1,PYROPTOSIS,POTENTIAL_THERAPEUTICS_FOR_SARS,TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR,TRAF6_MEDIATED_IRF7_ACTIVATION_IN_TLR7_8_OR_9_SIGNALING,TRAF6_MEDIATED_IRF7_ACTIVATION,REGULATION_OF_IFNG_SIGNALING,INTERLEUKIN_12_FAMILY_SIGNALING,CELLULAR_RESPONSES_TO_STIMULI,TRAF3_DEPENDENT_IRF_ACTIVATION_PATHWAY,REGULATED_NECROSIS,DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES,DETOXIFICATION_OF_REACTIVE_OXYGEN_SPECIES.1,IRAK4_DEFICIENCY_TLR2_4,ANTIMICROBIAL_PEPTIDES,MYD88_INDEPENDENT_TLR4_CASCADE,NEUTROPHIL_DEGRANULATION,INTERLEUKIN_1_SIGNALING,PROGRAMMED_CELL_DEATH,MAPK1_ERK2_ACTIVATION,CELLULAR_RESPONSES_TO_STIMULI.1,INACTIVATION_OF_CSF3_G_CSF_SIGNALING,NEUTROPHIL_DEGRANULATION.1,MAPK1_ERK2_ACTIVATION.1,REGULATION_OF_IFNG_SIGNALING.1,PURINERGIC_SIGNALING_IN_LEISHMANIASIS_INFECTION,INTERLEUKIN_21_SIGNALING,SIGNALING_BY_CSF3_G_CSF,INTERFERON_ALPHA_BETA_SIGNALING.1,TOLL_LIKE_RECEPTOR_9_TLR9_CASCADE.1,ANTIMICROBIAL_PEPTIDES.1,DEFENSINS,SARS_COV_1_HOST_INTERACTIONS,SARS_COV_1_INFECTION,CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA,TICAM1_DEPENDENT_ACTIVATION_OF_IRF3_IRF7,CELLULAR_RESPONSE_TO_CHEMICAL_STRESS,MYD88_INDEPENDENT_TLR4_CASCADE.1,DDX58_IFIH1_MEDIATED_INDUCTION_OF_INTERFERON_ALPHA_BETA.1,CYTOSOLIC_SENSORS_OF_PATHOGEN_ASSOCIATED_DNA.1,TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR.1,NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING,ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES,GENE_AND_PROTEIN_EXPRESSION_BY_JAK_STAT_SIGNALING_AFTER_INTERLEUKIN_12_STIMULATION,ROS_AND_RNS_PRODUCTION_IN_PHAGOCYTES.1,INTERFERON_GAMMA_SIGNALING.1,OVARIAN_TUMOR_DOMAIN_PROTEASES,TOLL_LIKE_RECEPTOR_4_TLR4_CASCADE,ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON,SIGNALING_BY_SCF_KIT,INTERLEUKIN_2_FAMILY_SIGNALING,ACTIVATION_OF_IRF3_IRF7_MEDIATED_BY_TBK1_IKK_EPSILON.1,ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES,INTERLEUKIN_12_SIGNALING,BETA_DEFENSINS,REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND,REGULATION_OF_TLR_BY_ENDOGENOUS_LIGAND.1,ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS,PROGRAMMED_CELL_DEATH.1,RAF_INDEPENDENT_MAPK1_3_ACTIVATION,DEFENSINS.1,ALTERNATIVE_COMPLEMENT_ACTIVATION,IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN,ALTERNATIVE_COMPLEMENT_ACTIVATION.1,RAF_INDEPENDENT_MAPK1_3_ACTIVATION.1,PYROPTOSIS.1,TRAF6_MEDIATED_NF_KB_ACTIVATION,CELLULAR_RESPONSE_TO_HEAT_STRESS,REGULATED_NECROSIS.1,ACYL_CHAIN_REMODELING_OF_CL,INTERLEUKIN_21_SIGNALING.1,INTERLEUKIN_20_FAMILY_SIGNALING,HEMOSTASIS,LEISHMANIA_INFECTION,INFECTION_WITH_MYCOBACTERIUM_TUBERCULOSIS,ANTIGEN_PROCESSING_CROSS_PRESENTATION,CELLULAR_RESPONSE_TO_CHEMICAL_STRESS.1,ATTENUATION_PHASE,DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION,STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES,DEX_H_BOX_HELICASES_ACTIVATE_TYPE_I_IFN_AND_INFLAMMATORY_CYTOKINES_PRODUCTION.1,SENESCENCE_ASSOCIATED_SECRETORY_PHENOTYPE_SASP,FOXO_MEDIATED_TRANSCRIPTION_OF_OXIDATIVE_STRESS_METABOLIC_AND_NEURONAL_GENES,RUNX1_REGULATES_TRANSCRIPTION_OF_GENES_INVOLVED_IN_DIFFERENTIATION_OF_KERATINOCYTES,INTERLEUKIN_1_PROCESSING,INTERLEUKIN_18_SIGNALING,INTERLEUKIN_2_FAMILY_SIGNALING.1,ANTIVIRAL_MECHANISM_BY_IFN_STIMULATED_GENES.1,INTERLEUKIN_1_FAMILY_SIGNALING.1,INTERLEUKIN_17_SIGNALING,INTERLEUKIN_1_PROCESSING.1,SYNTHESIS_OF_5_EICOSATETRAENOIC_ACIDS,MAPK3_ERK1_ACTIVATION,INTERLEUKIN_9_SIGNALING,CD163_MEDIATING_AN_ANTI_INFLAMMATORY_RESPONSE,ADAPTIVE_IMMUNE_SYSTEM,INTERLEUKIN_7_SIGNALING,MAPK3_ERK1_ACTIVATION.1,STAT3_NUCLEAR_EVENTS_DOWNSTREAM_OF_ALK_SIGNALING,HSF1_DEPENDENT_TRANSACTIVATION,SIGNALING_BY_LEPTIN,INTERLEUKIN_15_SIGNALING,INTERLEUKIN_27_SIGNALING,REGULATION_OF_HSF1_MEDIATED_HEAT_SHOCK_RESPONSE,INTERLEUKIN_35_SIGNALLING,SIGNALING_BY_PDGFRA_TRANSMEMBRANE_JUXTAMEMBRANE_AND_KINASE_DOMAIN_MUTANTS,BETA_DEFENSINS.1,TAK1_DEPENDENT_IKK_AND_NF_KAPPA_B_ACTIVATION,NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE,ZBP1_DAI_MEDIATED_INDUCTION_OF_TYPE_I_IFNS.1,REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA,ATTENUATION_PHASE.1,IRF3_MEDIATED_INDUCTION_OF_TYPE_I_IFN.1,ADVANCED_GLYCOSYLATION_ENDPRODUCT_RECEPTOR_SIGNALING,NF_KB_ACTIVATION_THROUGH_FADD_RIP_1_PATHWAY_MEDIATED_BY_CASPASE_8_AND_10,CELLULAR_RESPONSE_TO_HEAT_STRESS.1,INTERLEUKIN_15_SIGNALING.1,NEGATIVE_REGULATORS_OF_DDX58_IFIH1_SIGNALING.1,NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS,REGULATION_OF_INNATE_IMMUNE_RESPONSES_TO_CYTOSOLIC_DNA.1,DEUBIQUITINATION,CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION,STING_MEDIATED_INDUCTION_OF_HOST_IMMUNE_RESPONSES.1,HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND,RIP_MEDIATED_NFKB_ACTIVATION_VIA_ZBP1,G_ALPHA_I_SIGNALLING_EVENTS,SIGNALING_BY_PTK6,INTRINSIC_PATHWAY_FOR_APOPTOSIS,SIGNALING_BY_CYTOSOLIC_FGFR1_FUSION_MUTANTS,INACTIVATION_OF_CSF3_G_CSF_SIGNALING.1,NUCLEOTIDE_BINDING_DOMAIN_LEUCINE_RICH_REPEAT_CONTAINING_RECEPTOR_NLR_SIGNALING_PATHWAYS.1,HSP90_CHAPERONE_CYCLE_FOR_STEROID_HORMONE_RECEPTORS_SHR_IN_THE_PRESENCE_OF_LIGAND.1,NUCLEAR_EVENTS_STIMULATED_BY_ALK_SIGNALING_IN_CANCER,CHEMOKINE_RECEPTORS_BIND_CHEMOKINES,ARACHIDONIC_ACID_METABOLISM,INTERLEUKIN_17_SIGNALING.1,SIGNALING_BY_PDGFR_IN_DISEASE,SIGNALING_BY_KIT_IN_DISEASE,ARACHIDONIC_ACID_METABOLISM.1,PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION,NEF_MEDIATES_DOWN_MODULATION_OF_CELL_SURFACE_RECEPTORS_BY_RECRUITING_THEM_TO_CLATHRIN_ADAPTERS,PLATELET_ACTIVATION_SIGNALING_AND_AGGREGATION.1,CYTOPROTECTION_BY_HMOX1,JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1,SIGNALING_BY_CSF3_G_CSF.1,NITRIC_OXIDE_STIMULATES_GUANYLATE_CYCLASE.1,CHAPERONE_MEDIATED_AUTOPHAGY,SIGNALING_BY_RECEPTOR_TYROSINE_KINASES,FOXO_MEDIATED_TRANSCRIPTION,RESPONSE_OF_MTB_TO_PHAGOCYTOSIS,HSF1_DEPENDENT_TRANSACTIVATION.1,JNK_C_JUN_KINASES_PHOSPHORYLATION_AND_ACTIVATION_MEDIATED_BY_ACTIVATED_HUMAN_TAK1.1,ACTIVATED_TAK1_MEDIATES_P38_MAPK_ACTIVATION,REGULATION_OF_IFNA_IFNB_SIGNALING.1
Yes 10/11/22,2021,seven-band grouper (Hyporthodus septemfasciatus),M,Tropical,Hyporthodus septemfasciatus,Epinephelidae,20,25,5,Narrow,Juvenile ,Juvenile,Not stated,Exp,21,Within,17,-4,Decrease,Below,-3,-8,-3,37 days at 17C; compared with control,Protein,Colourimetric,Brain tissue lysate,Protein,Granzyme B activity,10,Increase,Viral. Looks like viral challenge and temperature change at same time,Viral,Y,Korea ,Aquaculture,6,2,8,204,Chronic,Chronic,"Krishnan, R., Jang, Y.S., Kim, J.O. and Oh, M.J., 2021. Altered expression of immune factors in sevenband grouper, Hyporthodus septemfasciatus following nervous necrosis virus challenge at optimal and suboptimal temperatures. Fish & Shellfish Immunology, 119, pp.442-451.",,Unknown,Unknown,Unknown,Granzyme B activity,GZMB,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,seven-band grouper (Hyporthodus septemfasciatus),M,Tropical,Hyporthodus septemfasciatus,Epinephelidae,20,25,5,Narrow,Juvenile ,Juvenile,Not stated,Exp,21,Within,17,-4,Decrease,Below,-3,-8,-3,17C for 30 days,Protein,ELISA,Serum,Protein,IgM-antigen specific,1,Same,Viral. Looks like viral challenge and temperature change at same time,Viral,Y,Korea ,Aquaculture,6,2,8,198,Chronic,Chronic,"Krishnan, R., Jang, Y.S., Kim, J.O. and Oh, M.J., 2021. Altered expression of immune factors in sevenband grouper, Hyporthodus septemfasciatus following nervous necrosis virus challenge at optimal and suboptimal temperatures. Fish & Shellfish Immunology, 119, pp.442-451.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,seven-band grouper (Hyporthodus septemfasciatus),M,Tropical,Hyporthodus septemfasciatus,Epinephelidae,20,25,5,Narrow,Juvenile ,Juvenile,Not stated,Exp,21,Within,17,-4,Decrease,Below,-3,-8,-3,17C for 30 days,Protein activity,MPO activity,Serum,Protein,MPO,3,Increase,Viral. Looks like viral challenge and temperature change at same time,Viral,Y,Korea ,Aquaculture,6,2,8,224,Chronic,Chronic,"Krishnan, R., Jang, Y.S., Kim, J.O. and Oh, M.J., 2021. Altered expression of immune factors in sevenband grouper, Hyporthodus septemfasciatus following nervous necrosis virus challenge at optimal and suboptimal temperatures. Fish & Shellfish Immunology, 119, pp.442-451.",,Unknown,mpx,Unknown,mpx,MPO,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,5,-5,Decrease,Within,2,-6,2,3 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,780,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,5,-5,Decrease,Within,2,-6,2,6 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,0.5,Decrease,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,782,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,5,-5,Decrease,Within,2,-6,2,9 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,0.25,Decrease,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,784,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,5,-5,Decrease,Within,2,-6,2,18 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,0.3,Decrease,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,786,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,5,-5,Decrease,Within,2,-6,2,18 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,787,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,5,-5,Decrease,Within,2,-6,2,18 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,0.5,Decrease,Bacterial x Chemical x Other,Bacterial x in vitro IgM specific for LPS x vaccine,Y,Norway ,Aquaculture,11,not stated,51,788,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Channel catfish (Ictalarus punctatus),F,Subtropical,Ictalarus punctatus,Ictaluridae,10,32,22,Wide,adult ,Adult,Not stated,Exp ,23,Within,15,-8,Decrease,Within,5,-17,5,1 week acclimation and then time course post challenge - 12 weeks,Cellular ,ELISA,Serum,Protein,IgM-antigen specific,0.5,Decrease,Chemical,DNP-KLH,N,USA ,Aquaculture,12,not stated,55,842,Chronic,Chronic,"Lange, M.D. and Webster, C.D., 2017. The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus). Fish & shellfish immunology, 70, pp.493-497.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Channel catfish (Ictalarus punctatus),F,Subtropical,Ictalarus punctatus,Ictaluridae,10,32,22,Wide,adult ,Adult,Not stated,Exp ,23,Within,15,-8,Decrease,Within,5,-17,5,1 week acclimation and then time course post challenge - 12 weeks,Cellular ,ELISA,Mucous,Protein,IgM-antigen specific,0.5,Decrease,Chemical,DNP-KLH,N,USA ,Aquaculture,12,not stated,55,844,Chronic,Chronic,"Lange, M.D. and Webster, C.D., 2017. The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus). Fish & shellfish immunology, 70, pp.493-497.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp,25,Within,21,-4,Decrease,Within,7,-12,7,>14 days. Temperature attained pre vaccine and measured day 14 (time course done but this is the peak),Cellular,ELISA,Serum,Protein,IgM-antigen specific,0.5,Decrease,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,20,not stated ,30,482,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Mo, X.B., Du, J.J. and Li, A.X., 2020. Influence of temperature on the vaccine efficacy against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 521, p.734943.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2016,Wuchang bream (Megalobrama amblycephala),F,Temperate,Megalobrama amblycephala,Xenocyprididae,10,20,10,Narrow,77g,Not stated,Not stated,Exp ,25,Above,32,7,Increase,Above,22,12,12,24 hours,Cellular ,kits,Liver,Protein,SOD,0.7,Decrease,Viral,Viral,Y,China,Aquaculture,15,3,65,921,Acute,Acute,"Liu, B., Xu, P., Brown, P.B., Xie, J., Ge, X., Miao, L., Zhou, Q., Ren, M. and Pan, L., 2016. The effect of hyperthermia on liver histology, oxidative stress and disease resistance of the Wuchang bream, Megalobrama amblycephala. Fish & Shellfish Immunology, 52, pp.317-324.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2022,Antarctic Nototheniidae and non-Antarctic sister lineage Bovichtidae,M,Polar,Notothenia rossii ,Nototheniidae,-5,-1,4,Narrow,Adult,Adult,Not stated,Exp,2,Above,6,4,Increase,Above,11,7,7,24 hours ,Cellular ,turbidimetric assay,plasma,Protein,Lysozyme,0.9,Decrease,Chemical,LPS (only looking at LPS challenged for both temperatures),N,China ,Wild,6,not stated ,2,33,Acute,Acute,"Sousa, C., Fernandes, S.A., Cardoso, J.C., Wang, Y., Zhai, W., Guerreiro, P.M., Chen, L., Canário, A.V. and Power, D.M., 2022. Toll-Like Receptor Evolution: Does Temperature Matter?. Frontiers in immunology, 13.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Atlantic salmon (Salmo salar L.),M + F + B,Temperate,Salmo salar,Salmonidae,2,9,7,Narrow,not stated ,Not stated,Not stated,Exp,12,Above,20,8,Increase,Above,18,11,11,4 weeks and 24 hours post vaccine,Cellular,,plasma,Protein,Hemolytic activity of complement,0.7,Decrease,Other,vaccine,N,Canada ,Aquaculture,6,not stated,29,459,Chronic,Acute,"Zanuzzo, F.S., Beemelmanns, A., Hall, J.R., Rise, M.L. and Gamperl, A.K., 2020. The innate immune response of Atlantic salmon (Salmo salar) is not negatively affected by high temperature and moderate hypoxia. Frontiers in immunology, 11, p.1009.",complement,Unknown,c9,Unknown,c9,C9,Unknown,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Atlantic salmon (Salmo salar L.),M + F + B,Temperate,Salmo salar,Salmonidae,2,9,7,Narrow,not stated ,Not stated,Not stated,Exp,12,Above,20,8,Increase,Above,18,11,11,4 weeks and 24 hours post vaccine,Cellular,,plasma,Protein,Lysozyme,1.3,Increase,Other,Vaccine,N,Canada ,Aquaculture,6,not stated,29,466,Chronic,Acute,"Zanuzzo, F.S., Beemelmanns, A., Hall, J.R., Rise, M.L. and Gamperl, A.K., 2020. The innate immune response of Atlantic salmon (Salmo salar) is not negatively affected by high temperature and moderate hypoxia. Frontiers in immunology, 11, p.1009.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,15,5,Increase,Above,12,4,4,3 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,2,Increase,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,781,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,15,5,Increase,Above,12,4,4,6 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,2,Increase,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,783,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,15,5,Increase,Above,12,4,4,9 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,1.2,Increase,Bacterial x Other,Bacterial x Vaccine,Y,Norway ,Aquaculture,10,not stated,51,785,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Atlantic lumpfish (Cyclopterus lumpusL.),M,Polar,Cyclopterus lumpus,Cyclopteridae,3,11,8,Narrow,Not stated,Not stated,M,Exp ,10,Within,15,5,Increase,Above,12,4,4,18 weeks post vaccine,Protein,ELISA,Serum,Protein,IgM-antigen specific,0.5,Decrease,Bacterial x Chemical x Other,Bacterial x in vitro IgM specific for LPS x vaccine,Y,Norway ,Aquaculture,12,not stated,51,789,Chronic,Chronic,"Erkinharju, T., Dalmo, R.A., Vågsnes, Ø., Hordvik, I. and Seternes, T., 2018. Vaccination of Atlantic lumpfish (Cyclopterus lumpus L.) at a low temperature leads to a low antibody response against Aeromonas salmonicida. Journal of fish diseases, 41(4), pp.613-623.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2018,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Juvenile,Juvenile,Not stated,Exp ,30,Within,35,5,Increase,Above,21,2,2,"28 days+, samples 28 days post vaccine",Cellular,qPCR,Serum,Protein,Catalase,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,3,4,48,752,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Luo, H.L., Lu, G.L. and Li, A.X., 2018. The effect of intermittent hypoxia under different temperature on the immunomodulation in Streptococcus agalactiae vaccinated Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology, 79, pp.181-192.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 14/11/22,2018,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Juvenile,Juvenile,Not stated,Exp ,30,Within,35,5,Increase,Above,21,2,2,"28 days+, samples 28 days post vaccine",Cellular,qPCR,Serum,Protein,GSH-Px,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,3,4,48,753,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Luo, H.L., Lu, G.L. and Li, A.X., 2018. The effect of intermittent hypoxia under different temperature on the immunomodulation in Streptococcus agalactiae vaccinated Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology, 79, pp.181-192.",,Unknown,gss,Unknown,gss,GSS,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2018,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Juvenile,Juvenile,Not stated,Exp ,30,Within,35,5,Increase,Above,21,2,2,"28 days+, samples 28 days post vaccine",Cellular,qPCR,Serum,Protein,MDA,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,3,4,48,760,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Luo, H.L., Lu, G.L. and Li, A.X., 2018. The effect of intermittent hypoxia under different temperature on the immunomodulation in Streptococcus agalactiae vaccinated Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology, 79, pp.181-192.",,Unknown,ifih1,Unknown,ifih1,IFIH1,Unknown,0,0,0,0,1,1,0,0,0,1,1,0,1,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2018,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Juvenile,Juvenile,Not stated,Exp ,30,Within,35,5,Increase,Above,21,2,2,"28 days+, samples 28 days post vaccine",Cellular,qPCR,Serum,Protein,SOD,0.8,Decrease,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,3,4,48,761,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Luo, H.L., Lu, G.L. and Li, A.X., 2018. The effect of intermittent hypoxia under different temperature on the immunomodulation in Streptococcus agalactiae vaccinated Nile tilapia (Oreochromis niloticus). Fish & shellfish immunology, 79, pp.181-192.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,olive flounder (Paralichthys olivaceus),M,Subtropical,Paralichthys olivaceus,Paralichthyidae,26,29,3,Narrow,Not stated,Not stated,Not stated,Exp,10,Below,20,10,Increase,Below,-6,-9,-6,"14 days max (different groups raised Temp at different times after challenge; measured responses daily afterwards). Challenge at time 0, the  water temp increased at same time",Cellular ,Cell count ,Spleen,Other,% of CD8+ lymphocytes,2,Increase,Viral,Viral,Y,China ,Aquaculture,90,2,18,334,Chronic,Chronic,"Wang, H., Tang, X., Xing, J., Sheng, X., Chi, H. and Zhan, W., 2021. Effect of raising water temperature on proliferation of hirame novirhabdovirus (HIRRV) and antiviral response of olive flounder (Paralichthys olivaceus). Aquaculture, 540, p.736751.",,Unknown,Unknown,Unknown,cd8a,CD8A,Unknown,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp ,29,Within,33,4,Increase,Within,19,0,0,14 days; measured at day 1 post infection,Cellular ,Assay kits,,Protein,Catalase,0.6,Decrease,Bacterial,Bacterial,Y,China ,Aquaculture,35,3,21,378,Chronic,Acute,"He, R.Z., Li, Z.C., Li, S.Y. and Li, A.X., 2021. Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 531, p.735877.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp ,29,Within,33,4,Increase,Within,19,0,0,14 days; measured at day 1 post infection,Cellular ,Assay kits,,Protein,Lysozyme,1,Same,Bacterial,Bacterial,Y,China ,Aquaculture,35,3,21,388,Chronic,Acute,"He, R.Z., Li, Z.C., Li, S.Y. and Li, A.X., 2021. Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 531, p.735877.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp ,29,Within,33,4,Increase,Within,19,0,0,14 days; measured at day 1 post infection,Cellular ,Assay kits,,Protein,SOD,0.5,Decrease,Bacterial,Bacterial,Y,China ,Aquaculture,35,3,21,394,Chronic,Acute,"He, R.Z., Li, Z.C., Li, S.Y. and Li, A.X., 2021. Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 531, p.735877.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,Juvenile ,Juvenile,Not stated,Exp ,20,Below,28,8,Increase,Within,3.6,-1.1,-1.1,12 days + 24 hours post bacteria,Cellular ,Assay ,serum activity,Protein,ACP,1.3,Increase,Bacterial x Other,Bacterial x Sodium alginate but comparing control,Y,Taiwan,Aquaculture,6,2,60,886,Chronic,Acute,"Lee, P.P., Lin, Y.H., Chen, M.C. and Cheng, W., 2017. Dietary administration of sodium alginate ameliorated stress and promoted immune resistance of grouper Epinephelus coioides under cold stress. Fish & Shellfish Immunology, 65, pp.127-135.",alternative complement pathway,,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,Juvenile ,Juvenile,Not stated,Exp ,20,Below,28,8,Increase,Within,3.6,-1.1,-1.1,12 days + 24 hours post bacteria,Cellular ,Assay ,serum activity,Protein,Lysozyme,1.2,Increase,Bacterial x Other,Bacterial x Sodium alginate but comparing control,Y,Taiwan,Aquaculture,6,2,60,887,Chronic,Acute,"Lee, P.P., Lin, Y.H., Chen, M.C. and Cheng, W., 2017. Dietary administration of sodium alginate ameliorated stress and promoted immune resistance of grouper Epinephelus coioides under cold stress. Fish & Shellfish Immunology, 65, pp.127-135.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,Juvenile ,Juvenile,Not stated,Exp ,20,Below,28,8,Increase,Within,3.6,-1.1,-1.1,12 days + 24 hours post bacteria,Cellular ,kit,head kidney leucocytes,Protein,SOD,1.8,Increase,Bacterial x Other,Bacterial x Sodium alginate but comparing control,Y,Taiwan,Aquaculture,6,2,60,890,Chronic,Acute,"Lee, P.P., Lin, Y.H., Chen, M.C. and Cheng, W., 2017. Dietary administration of sodium alginate ameliorated stress and promoted immune resistance of grouper Epinephelus coioides under cold stress. Fish & Shellfish Immunology, 65, pp.127-135.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2018,common carp (Cyprinus carpio L.),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,one year old,Juvenile,Not stated,Exp ,20,Within,30,10,Increase,Within,27,-5,-5,"30 days , then back to 20C for bacterial challenge, sampled at 24hour post bacteria",Cellular ,Spectrophotometer,Serum,Protein,Ig,1,Same,Bacterial,Bacterial,Y,Hungary ,Aquaculture,10,3,49,768,Chronic,Acute,"Shahi, N., Ardó, L., Fazekas, G., Gócza, E., Kumar, S., Rèvèsz, N., Sándor, Z.J., Molnár, Z., Jeney, G. and Jeney, Z., 2018. Immunogene expression in head kidney and spleen of common carp (Cyprinus carpio L.) following thermal stress and challenge with Gram-negative bacterium, Aeromonas hydrophila. Aquaculture International, 26(3), pp.727-741.",,Unknown,ighv,Unknown,ighv,IGH,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp ,29,Within,33,4,Increase,Within,19,0,0,14 days; measured at day 7 post infection,Cellular ,Assay kits,,Protein,Catalase,0.6,Decrease,Bacterial,Bacterial,Y,China ,Aquaculture,35,3,21,377,Chronic,Chronic,"He, R.Z., Li, Z.C., Li, S.Y. and Li, A.X., 2021. Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 531, p.735877.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp ,29,Within,33,4,Increase,Within,19,0,0,14 days; measured at day 7 post infection,Cellular ,Assay kits,,Protein,Lysozyme,1.7,Increase,Bacterial,Bacterial,Y,China ,Aquaculture,35,3,21,387,Chronic,Chronic,"He, R.Z., Li, Z.C., Li, S.Y. and Li, A.X., 2021. Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 531, p.735877.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp ,29,Within,33,4,Increase,Within,19,0,0,14 days; measured at day 7 post infection,Cellular ,Assay kits,,Protein,SOD,1,Same,Bacterial,Bacterial,Y,China ,Aquaculture,35,3,21,393,Chronic,Chronic,"He, R.Z., Li, Z.C., Li, S.Y. and Li, A.X., 2021. Development of an immersion challenge model for Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 531, p.735877.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,seven-band grouper (Hyporthodus septemfasciatus),M,Tropical,Hyporthodus septemfasciatus,Epinephelidae,20,25,5,Narrow,Juvenile ,Juvenile,Not stated,Exp,21,Within,25,4,Increase,Within,5,0,0,37 days at 25C; compared with control,Protein,Colourimetric,Brain tissue lysate,Protein,Granzyme B activity,7,Increase,Viral. Looks like viral challenge and temperature change at same time,Viral,Y,Korea ,Aquaculture,6,2,8,205,Chronic,Chronic,"Krishnan, R., Jang, Y.S., Kim, J.O. and Oh, M.J., 2021. Altered expression of immune factors in sevenband grouper, Hyporthodus septemfasciatus following nervous necrosis virus challenge at optimal and suboptimal temperatures. Fish & Shellfish Immunology, 119, pp.442-451.",,Unknown,Unknown,Unknown,Granzyme B activity,GZMB,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,seven-band grouper (Hyporthodus septemfasciatus),M,Tropical,Hyporthodus septemfasciatus,Epinephelidae,20,25,5,Narrow,Juvenile ,Juvenile,Not stated,Exp,21,Within,25,4,Increase,Within,5,0,0,25C for 30 days,Protein,ELISA,Serum,Protein,IgM-antigen specific,5,Increase,Viral. Looks like viral challenge and temperature change at same time,Viral,Y,Korea ,Aquaculture,6,2,8,199,Chronic,Chronic,"Krishnan, R., Jang, Y.S., Kim, J.O. and Oh, M.J., 2021. Altered expression of immune factors in sevenband grouper, Hyporthodus septemfasciatus following nervous necrosis virus challenge at optimal and suboptimal temperatures. Fish & Shellfish Immunology, 119, pp.442-451.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,seven-band grouper (Hyporthodus septemfasciatus),M,Tropical,Hyporthodus septemfasciatus,Epinephelidae,20,25,5,Narrow,Juvenile ,Juvenile,Not stated,Exp,21,Within,25,4,Increase,Within,5,0,0,25C for 30 days,Protein activity,MPO activity,Serum,Protein,MPO,10,Increase,Viral. Looks like viral challenge and temperature change at same time,Viral,Y,Korea ,Aquaculture,6,2,8,225,Chronic,Chronic,"Krishnan, R., Jang, Y.S., Kim, J.O. and Oh, M.J., 2021. Altered expression of immune factors in sevenband grouper, Hyporthodus septemfasciatus following nervous necrosis virus challenge at optimal and suboptimal temperatures. Fish & Shellfish Immunology, 119, pp.442-451.",,Unknown,mpx,Unknown,mpx,MPO,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Channel catfish (Ictalarus punctatus),F,Subtropical,Ictalarus punctatus,Ictaluridae,10,32,22,Wide,adult ,Adult,Not stated,Exp ,23,Within,30,7,Increase,Within,20,-2,-2,1 week acclimation and then time course post challenge - 12 weeks,Cellular ,ELISA,Serum,Protein,IgM-antigen specific,1,Same,Chemical,DNP-KLH,N,USA ,Aquaculture,12,not stated,55,843,Chronic,Chronic,"Lange, M.D. and Webster, C.D., 2017. The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus). Fish & shellfish immunology, 70, pp.493-497.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Channel catfish (Ictalarus punctatus),F,Subtropical,Ictalarus punctatus,Ictaluridae,10,32,22,Wide,adult ,Adult,Not stated,Exp ,23,Within,30,7,Increase,Within,20,-2,-2,1 week acclimation and then time course post challenge - 12 weeks,Cellular ,ELISA,Mucous,Protein,IgM-antigen specific,1,Same,Chemical,DNP-KLH,N,USA ,Aquaculture,12,not stated,55,845,Acute,Chronic,"Lange, M.D. and Webster, C.D., 2017. The effect of temperature on the mucosal IgM antibody response to DNP-KLH in channel catfish (Ictalurus punctatus). Fish & shellfish immunology, 70, pp.493-497.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp,25,Within,29,4,Increase,Within,15,-4,-4,>14 days. Temperature attained pre vaccine and measured day 14 (time course done but this is the peak),Cellular,ELISA,Serum,Protein,IgM-antigen specific,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,20,not stated ,30,483,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Mo, X.B., Du, J.J. and Li, A.X., 2020. Influence of temperature on the vaccine efficacy against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 521, p.734943.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Nile tilapia (Oreochromis niloticus),F + B,Tropical,Oreochromis niloticus,Cichlidae,14,33,19,Wide,Not stated,Not stated,Not stated,Exp,25,Within,33,8,Increase,Within,19,0,0,>14 days. Temperature attained pre vaccine and measured day 14 (time course done but this is the peak),Cellular,ELISA,Serum,Protein,IgM-antigen specific,1,Same,Bacterial x Other,Bacterial x Vaccine,Y,China ,Aquaculture,20,not stated ,30,484,Chronic,Chronic,"Wang, J., Lu, D.Q., Jiang, B., Mo, X.B., Du, J.J. and Li, A.X., 2020. Influence of temperature on the vaccine efficacy against Streptococcus agalactiae in Nile tilapia (Oreochromis niloticus). Aquaculture, 521, p.734943.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,8,-6,Decrease,Above,6.6,3.5,3.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,Catalase,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,846,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,10,-4,Decrease,Above,8.6,5.5,5.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,Catalase,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,847,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,12,-2,Decrease,Above,10.6,7.5,7.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,Catalase,0.9,Decrease,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,848,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,8,-6,Decrease,Above,6.6,3.5,3.5,4 months ,Enzyme activity,Measure of activity - turbidimetric assay,plasma,Protein,Lysozyme,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,851,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,10,-4,Decrease,Above,8.6,5.5,5.5,4 months ,Enzyme activity,Measure of activity - turbidimetric assay,plasma,Protein,Lysozyme,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,852,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,12,-2,Decrease,Above,10.6,7.5,7.5,4 months ,Enzyme activity,Measure of activity - turbidimetric assay,plasma,Protein,Lysozyme,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,853,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,8,-6,Decrease,Above,6.6,3.5,3.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,SOD,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,865,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,10,-4,Decrease,Above,8.6,5.5,5.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,SOD,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,866,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,12,-2,Decrease,Above,10.6,7.5,7.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,SOD,1,Same,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,867,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Yellow croaker ,M + B,Temperate,Larimichthys crocea,Sciaenidae,20.8,24.7,3.9,Narrow,Not stated,Not stated,Not stated,Exp,20,Below,30,10,Increase,Above,9.2,5.3,5.3,2 hours (acute stress); measured at 30 mins,Cellular ,Commercial kit,Serum  ,Protein,IgM-antigen specific,1.5,Increase,NA,NA,NA,China ,Aquaculture,3,6,26,445,Acute,NA,"Cai, X., Zhang, J., Lin, L., Li, Y., Liu, X. and Wang, Z., 2020. Study of a noninvasive detection method for the high-temperature stress response of the large yellow croaker (Larimichthys crocea). Aquaculture Reports, 18, p.100514.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Acipenser gueldenstaedtii (Russian sturgeon),M + F + B,Temperate,Acipenser gueldenstaedtii,Acipenseridae,10,20,10,Narrow,2 years,Not stated,F,Exp ,18,Within,24,6,Increase,Above,14,4,4,37 days,Cellular ,Assay ,,Protein,ACP,0.5,Decrease,NA,NA,NA,Uruguay,Aquaculture,20,not stated,58,882,Chronic,NA,"Castellano, M., Silva-Álvarez, V., Fernández-López, E., Mauris, V., Conijeski, D., Villarino, A. and Ferreira, A.M., 2017. Russian sturgeon cultured in a subtropical climate shows weaken innate defences and a chronic stress response. Fish & Shellfish Immunology, 68, pp.443-451.",alternative complement pathway,,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,Acipenser gueldenstaedtii (Russian sturgeon),M + F + B,Temperate,Acipenser gueldenstaedtii,Acipenseridae,10,20,10,Narrow,2 years,Juvenile,F,Exp ,18,Within,24,6,Increase,Above,14,4,4,37 days,Cellular ,Assay ,,Protein,Lysozyme,1.5,Increase,NA,NA,NA,Uruguay,Aquaculture,20,not stated,58,883,Chronic,NA,"Castellano, M., Silva-Álvarez, V., Fernández-López, E., Mauris, V., Conijeski, D., Villarino, A. and Ferreira, A.M., 2017. Russian sturgeon cultured in a subtropical climate shows weaken innate defences and a chronic stress response. Fish & Shellfish Immunology, 68, pp.443-451.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Protein,Kits,Serum,Protein,C3,0.6,Decrease,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,289,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Activity based assay,Gills,Protein,GSH-Px,0.9,Decrease,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,291,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,gss,Unknown,gss,GSS,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Elisa ,Intestine,Protein,IL-10,0.6,Decrease,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,292,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,il10,Unknown,il10,IL10,Unknown,1,1,1,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Elisa ,Intestine,Protein,IL-1b,1,Same,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,293,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,il1b,Unknown,il1b,IL1B,interleukin superfamily,1,1,1,1,1,0,1,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Elisa ,Intestine,Protein,IL-4,1,Same,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,294,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,il4,Unknown,il4,IL4,Unknown,1,1,1,1,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Elisa ,Intestine,Protein,IL-6,1.2,Increase,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,295,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,il6,Unknown,il6,IL6,Unknown,1,1,1,1,0,0,1,0,0,1,0,0,0,1,1,0,0,0,1,0,1,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Protein,Kits,Serum ,Protein,iNOS,0.9,Decrease,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,296,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,Unknown,nos1apa,nos1apa,NOS2,Unknown,1,1,1,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Protein,Kits,Serum,Protein,Lysozyme,1,Same,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,297,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Activity based assay,Gills,Protein,MDA,15,Increase,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,299,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,ifih1,Unknown,ifih1,IFIH1,Unknown,0,0,0,0,1,1,0,0,0,1,1,0,1,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Protein,Kits,Serum ,Protein,NOS,1,Same,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,305,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,nos1apa,Unknown,nos1apa,NOS1,scaffold/adaptor potein,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Activity based assay,Gills,Protein,SOD,0.3,Decrease,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,302,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Spotted seabass(Lateolabrax maculatus),M + F + B,Subtropical,Lateolabrax maculatus,Lateolabracidae,12.7,26.3,13.6,Wide,Juvenile ,Juvenile,Not stated,Exp,27,Above,33,6,Increase,Above,20.3,6.7,6.7,14 days ,Cellular ,Elisa ,Intestine,Protein,TNF-a,1.5,Increase,Other,dietary arginine but comparing groups where these levels are the same; mid value so 2.44 % arginine,N,China,Aquaculture,9,4,16,304,Chronic,NA,"Cheng, Y., Li, X., Wang, L., Lu, K., Song, K., Ai, Q., Mai, K. and Zhang, C., 2021. Effects of dietary arginine levels on growth, immune function of physical barriers and serum parameters of spotted seabass (Lateolabrax maculatus) reared at different water temperatures. Aquaculture, 541, p.736812.",,TNFA,tnfa,Unknown,tnfa,TNF,intercellular signal molecule,1,1,1,1,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Plasma,Protein,ACP,1,Same,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,972,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",alternative complement pathway,,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Plasma,Protein,ACP,1,Same,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,973,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",alternative complement pathway,,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Plasma,Protein,ACP,1,Same,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,974,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",alternative complement pathway,,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Plasma,Protein,ACP,1,Same,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,975,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",alternative complement pathway,,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,Catalase,0.8,Decrease,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,976,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,Catalase,0.8,Decrease,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,977,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,Catalase,0.9,Decrease,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,978,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,Catalase,0.6,Decrease,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,979,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,GPx,0.7,Decrease,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,980,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,GPx,1.8,Increase,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,981,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,GPx,0.85,Decrease,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,982,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,GPx,0.15,Decrease,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,983,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,PEG/BCA based assay,Plasma,Protein,Ig,1,Same,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,984,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,ighv,Unknown,ighv,IGH,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,PEG/BCA based assay,Plasma,Protein,Ig,0.9,Decrease,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,985,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,ighv,Unknown,ighv,IGH,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,PEG/BCA based assay,Plasma,Protein,Ig,0.9,Decrease,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,986,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,ighv,Unknown,ighv,IGH,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,PEG/BCA based assay,Plasma,Protein,Ig,1.1,Increase,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,987,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,ighv,Unknown,ighv,IGH,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,turbidimetric method,Lysozyme activity in plasma,Protein,Lysozyme,0.9,Decrease,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,988,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,turbidimetric method,Lysozyme activity in plasma,Protein,Lysozyme,0.9,Decrease,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,989,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,turbidimetric method,Lysozyme activity in plasma,Protein,Lysozyme,0.5,Decrease,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,990,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,turbidimetric method,Lysozyme activity in plasma,Protein,Lysozyme,0.6,Decrease,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,991,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay - TMB based,Plasma,Protein,Peroxidase,0.7,Decrease,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,992,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay - TMB based,Plasma,Protein,Peroxidase,1.1,Increase,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,993,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay - TMB based,Plasma,Protein,Peroxidase,0.8,Decrease,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,994,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay - TMB based,Plasma,Protein,Peroxidase,0.8,Decrease,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,995,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,SOD,0.9,Decrease,Other,Diet - data are all from D0 diet,N,Spain ,Aquaculture,3,3,69,996,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,SOD,1,Same,Other,Diet - data are from D0.5 diet,N,Spain ,Aquaculture,3,3,69,997,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,SOD,1.1,Increase,Other,Diet - data are from D1 diet,N,Spain ,Aquaculture,3,3,69,998,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,turbot (Scophthalmus maximus),M + B,Temperate,Scophthalmus maximus,Scophthalmidae,5.9,11.9,6,Narrow,Juvenile - used at 31.6g,Juvenile,Not stated,Exp ,15,Above,20,5,Increase,Above,14.1,8.1,8.1,9 weeks,Cellular ,Functional assay,Liver  ,Protein,SOD,1.1,Increase,Other,Diet - data are from D2 diet,N,Spain ,Aquaculture,3,3,69,999,Chronic,NA,"Guerreiro, I., Pérez-Jiménez, A., Costas, B. and Oliva-Teles, A., 2014. Effect of temperature and short chain fructooligosaccharides supplementation on the hepatic oxidative status and immune response of turbot (Scophthalmus maximus). Fish & Shellfish Immunology, 40(2), pp.570-576.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Seabass (Dicentrarchus labrax),M + F + B,Subtropical,Dicentrarchus labrax,Moronidae,8,24,16,Wide,Juvenile ,Juvenile,Not stated,Exp ,22,Within,32,10,Increase,Above,24,8,8,Temperature raised f3.5C over three days and temp stayed at 32C for 18 days,,,Serum,Protein,Catalase,1.3,Increase,NA,NA,NA,Germany,Aquaculture,3,3,11,262,Chronic,NA,"Islam, M.J., Kunzmann, A., Henjes, J. and Slater, M.J., 2021. Can dietary manipulation mitigate extreme warm stress in fish? The case of European seabass, Dicentrarchus labrax. Aquaculture, 545, p.737153.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Seabass (Dicentrarchus labrax),M + F + B,Subtropical,Dicentrarchus labrax,Moronidae,8,24,16,Wide,Juvenile ,Juvenile,Not stated,Exp ,22,Within,32,10,Increase,Above,24,8,8,Temperature raised f3.5C over three days and temp stayed at 32C for 18 days,,,Serum,Protein,GPx,5,Increase,NA,NA,NA,Germany,Aquaculture,3,3,11,263,Chronic,NA,"Islam, M.J., Kunzmann, A., Henjes, J. and Slater, M.J., 2021. Can dietary manipulation mitigate extreme warm stress in fish? The case of European seabass, Dicentrarchus labrax. Aquaculture, 545, p.737153.",,Unknown,gpx1a,Unknown,gpx1a,GPX1,peroxidase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Seabass (Dicentrarchus labrax),M + F + B,Subtropical,Dicentrarchus labrax,Moronidae,8,24,16,Wide,Juvenile ,Juvenile,Not stated,Exp ,22,Within,32,10,Increase,Above,24,8,8,Temperature raised f3.5C over three days and temp stayed at 32C for 18 days,,,Serum,Protein,GR activity,1.2,Increase,NA,NA,NA,Germany,Aquaculture,3,3,11,264,Chronic,NA,"Islam, M.J., Kunzmann, A., Henjes, J. and Slater, M.J., 2021. Can dietary manipulation mitigate extreme warm stress in fish? The case of European seabass, Dicentrarchus labrax. Aquaculture, 545, p.737153.",,Unknown,nr3c1,Unknown,nr3c1,NR3C1,C4 zinc finger nuclear receptor,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Seabass (Dicentrarchus labrax),M + F + B,Subtropical,Dicentrarchus labrax,Moronidae,8,24,16,Wide,Juvenile ,Juvenile,Not stated,Exp ,22,Within,32,10,Increase,Above,24,8,8,Temperature raised f3.5C over three days and temp stayed at 32C for 18 days,Lysozyme activity,,Serum ,Protein,Lysozyme,0.5,Decrease,NA,NA,NA,Germany,Aquaculture,3,3,11,267,Chronic,NA,"Islam, M.J., Kunzmann, A., Henjes, J. and Slater, M.J., 2021. Can dietary manipulation mitigate extreme warm stress in fish? The case of European seabass, Dicentrarchus labrax. Aquaculture, 545, p.737153.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Seabass (Dicentrarchus labrax),M + F + B,Subtropical,Dicentrarchus labrax,Moronidae,8,24,16,Wide,Juvenile ,Juvenile,Not stated,Exp ,22,Within,32,10,Increase,Above,24,8,8,Temperature raised f3.5C over three days and temp stayed at 32C for 18 days,SOD activity,,Serum,Protein,SOD,1.3,Increase,NA,NA,NA,Germany,Aquaculture,3,3,11,269,Chronic,NA,"Islam, M.J., Kunzmann, A., Henjes, J. and Slater, M.J., 2021. Can dietary manipulation mitigate extreme warm stress in fish? The case of European seabass, Dicentrarchus labrax. Aquaculture, 545, p.737153.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,16,2,Increase,Above,14.6,11.5,11.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,Catalase,1.3,Increase,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,849,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,18,4,Increase,Above,16.6,13.5,13.5,4 months ,Enzyme activity,Kit,Liver,Protein,Catalase,1.3,Increase,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,850,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,16,2,Increase,Above,14.6,11.5,11.5,4 months ,Enzyme activity,Measure of activity - turbidimetric assay,plasma,Protein,Lysozyme,1.1,Increase,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,854,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,18,4,Increase,Above,16.6,13.5,13.5,4 months ,Cellular ,Measure of activity - turbidimetric assay,plasma,Protein,Lysozyme,1.2,Increase,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,855,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,16,2,Increase,Above,14.6,11.5,11.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,SOD,1.1,Increase,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,868,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2017,"sablefish, Anoplopoma fimbria",M,Deep-water,Anoplopoma fimbria,Anoplopomatidae,1.4,4.5,3.1,Narrow,juveniles ,Juvenile,Not stated,Exp ,14,Above,18,4,Increase,Above,16.6,13.5,13.5,4 months ,Enzyme activity,Kit,Liver  ,Protein,SOD,1.2,Increase,Other,Salinity,N,South Korea ,Aquaculture,7,3,56,869,Chronic,NA,"Kim, J.H., Park, H.J., Kim, K.W., Hwang, I.K., Kim, D.H., Oh, C.W., Lee, J.S. and Kang, J.C., 2017. Growth performance, oxidative stress, and non-specific immune responses in juvenile sablefish, Anoplopoma fimbria, by changes of water temperature and salinity. Fish physiology and biochemistry, 43(5), pp.1421-1431.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Waigieu seaperch ,M + B,Subtropical,Psammoperca waigiensis,Latidae,24.7,29.3,4.6,Narrow,Juvenile ,Juvenile,Not stated,Exp,28,Within,32,4,Increase,Above,7.3,2.7,2.7,10 weeks,Cellular ,Lyzozyme activity,Blood serum,Protein,Lyzozyme ,0.6,Decrease,NA,NA,NA,Vietnam,Aquaculture,10,9,13,276,Chronic,NA,"Le, M.H., Dinh, K.V., Pham, D.H., Phan, V.U. and Tran, V.H., 2021. Extreme temperature differently alters the effects of dietary vitamin C on the growth, immunity and pathogen resistance of Waigieu seaperch, Psammoperca waigiensis. Aquaculture Research, 52(11), pp.5383-5396.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019, yellow catfish (Pelteobagrus fulvidraco) ,F,Temperate,Pelteobagrus fulvidraco,Bagridae,16,25,9,Narrow,2.21g,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Above,16,7,7,"one day, measurements at day 2",Cellular ,ELISA,serum,Protein,C3,0.6,Decrease,Chemical,carotenoids but comparing controls so not a confounding factor,N,China ,Aquaculture,12,2,44,723,Acute,NA,"Liu, F., Qu, Y.K., Wang, A.M., Yu, Y.B., Yang, W.P., Lv, F. and Nie, Q., 2019. Effects of carotenoids on the growth performance, biochemical parameters, immune responses and disease resistance of yellow catfish (Pelteobagrus fulvidraco) under high-temperature stress. Aquaculture, 503, pp.293-303.",,Unknown,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019, yellow catfish (Pelteobagrus fulvidraco) ,F,Temperate,Pelteobagrus fulvidraco,Bagridae,16,25,9,Narrow,2.21g,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Above,16,7,7,"one day, measurements at day 2",Cellular ,colorimetric,Liver,Protein,Catalase,0.8,Decrease,Chemical,carotenoids but comparing controls so not a confounding factor,N,China ,Aquaculture,12,2,44,725,Acute,NA,"Liu, F., Qu, Y.K., Wang, A.M., Yu, Y.B., Yang, W.P., Lv, F. and Nie, Q., 2019. Effects of carotenoids on the growth performance, biochemical parameters, immune responses and disease resistance of yellow catfish (Pelteobagrus fulvidraco) under high-temperature stress. Aquaculture, 503, pp.293-303.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 14/11/22,2019, yellow catfish (Pelteobagrus fulvidraco) ,F,Temperate,Pelteobagrus fulvidraco,Bagridae,16,25,9,Narrow,2.21g,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Above,16,7,7,"one day, measurements at day 2",Cellular ,ELISA,Serum,Protein,Ig,1.2,Increase,Chemical,carotenoids but comparing controls so not a confounding factor,N,China ,Aquaculture,12,2,44,728,Acute,NA,"Liu, F., Qu, Y.K., Wang, A.M., Yu, Y.B., Yang, W.P., Lv, F. and Nie, Q., 2019. Effects of carotenoids on the growth performance, biochemical parameters, immune responses and disease resistance of yellow catfish (Pelteobagrus fulvidraco) under high-temperature stress. Aquaculture, 503, pp.293-303.",,Unknown,ighv,Unknown,ighv,IGH,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019, yellow catfish (Pelteobagrus fulvidraco) ,F,Temperate,Pelteobagrus fulvidraco,Bagridae,16,25,9,Narrow,2.21g,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Above,16,7,7,"one day, measurements at day 2",Cellular ,ELISA,Serum,Protein,Lysozyme,1.1,Increase,Chemical,carotenoids but comparing controls so not a confounding factor,N,China ,Aquaculture,12,2,44,731,Acute,NA,"Liu, F., Qu, Y.K., Wang, A.M., Yu, Y.B., Yang, W.P., Lv, F. and Nie, Q., 2019. Effects of carotenoids on the growth performance, biochemical parameters, immune responses and disease resistance of yellow catfish (Pelteobagrus fulvidraco) under high-temperature stress. Aquaculture, 503, pp.293-303.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019, yellow catfish (Pelteobagrus fulvidraco) ,F,Temperate,Pelteobagrus fulvidraco,Bagridae,16,25,9,Narrow,2.21g,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Above,16,7,7,"one day, measurements at day 2",Cellular ,Barbituric acid method,Serum,Protein,SOD,1,Same,Chemical,carotenoids but comparing controls so not a confounding factor,N,China ,Aquaculture,12,2,44,732,Acute,NA,"Liu, F., Qu, Y.K., Wang, A.M., Yu, Y.B., Yang, W.P., Lv, F. and Nie, Q., 2019. Effects of carotenoids on the growth performance, biochemical parameters, immune responses and disease resistance of yellow catfish (Pelteobagrus fulvidraco) under high-temperature stress. Aquaculture, 503, pp.293-303.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Tambaqui (Colossoma macropomum),F,Tropical,Colossoma macropomum,Serrasalmidae,22,28,6,Narrow,Juvenile ,Juvenile,Not stated,Exp,26,Within,29,3,Increase,Above,7,1,1,60 days ,Protein,CAT activity assay,Liver  ,Protein,Catalase,0.5,Decrease,Other,Light/day cycles. All data taken from 12/12 cycle,N,Brazil ,Aquaculture,3,3,15,284,Chronic,NA,"Pereira, L.A.L., Amanajás, R.D., de Oliveira, A.M., da Silva, M.D.N.P. and Val, A.L., 2021. Health of the Amazonian fish tambaqui (Colossoma macropomum): Effects of prolonged photoperiod and high temperature. Aquaculture, 541, p.736836.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Tambaqui (Colossoma macropomum),F,Tropical,Colossoma macropomum,Serrasalmidae,22,28,6,Narrow,Juvenile ,Juvenile,Not stated,Exp,26,Within,32,6,Increase,Above,10,4,4,60 days ,Protein,CAT activity assay,Liver  ,Protein,Catalase,0.4,Decrease,Other,Light/day cycles. All data taken from 12/12 cycle,N,Brazil ,Aquaculture,3,3,15,285,Chronic,NA,"Pereira, L.A.L., Amanajás, R.D., de Oliveira, A.M., da Silva, M.D.N.P. and Val, A.L., 2021. Health of the Amazonian fish tambaqui (Colossoma macropomum): Effects of prolonged photoperiod and high temperature. Aquaculture, 541, p.736836.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Tambaqui (Colossoma macropomum),F,Tropical,Colossoma macropomum,Serrasalmidae,22,28,6,Narrow,Juvenile ,Juvenile,Not stated,Exp ,26,Within,29,3,Increase,Above,7,1,1,60 days ,Cellular ,SOD activity assay,Liver  ,Protein,SOD,1.1,Increase,Other,Light/day cycles. All data taken from 12/12 cycle,N,Brazil ,Aquaculture,3,3,15,286,Chronic,NA,"Pereira, L.A.L., Amanajás, R.D., de Oliveira, A.M., da Silva, M.D.N.P. and Val, A.L., 2021. Health of the Amazonian fish tambaqui (Colossoma macropomum): Effects of prolonged photoperiod and high temperature. Aquaculture, 541, p.736836.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Channa punctata,F + B,Tropical,Channa punctata,Channidae,22,28,6,Narrow,Not stated,Not stated,Not stated,Exp ,25,Within,35,10,Increase,Above,13,7,7,7 days ,Cellular ,ELISA,Liver,Protein,HSP70,1.4,Increase,NA,NA,NA,India,Aquaculture,5,3,22,398,Chronic,NA,"Singh, S.P., Ahmad, T., Sharma, J. and Chakrabarti, R., 2021. Effect of temperature on food consumption, immune system, antioxidant enzymes, and heat shock protein 70 of Channa punctata (Bloch, 1793). Fish Physiology and Biochemistry, 47(1), pp.79-91.",,Unknown,hsp70.1,Unknown,hsp70.1,HSPA4,Hsp70 family chaperone,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,24,7,Increase,Above,22,2,2,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,ALP activity,1.5,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,112,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",Protein - alkaline phosphatase,,alpl,Unknown,alpl,ALPL,phosphatase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,27,10,Increase,Above,25,5,5,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,ALP activity,1.3,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,113,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",Protein - alkaline phosphatase,,alpl,Unknown,alpl,ALPL,phosphatase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,24,7,Increase,Above,22,2,2,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,Catalase,1.8,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,115,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,27,10,Increase,Above,25,5,5,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,Catalase,2,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,116,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,24,7,Increase,Above,22,2,2,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,Lysozyme,1.3,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,118,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,27,10,Increase,Above,25,5,5,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,Lysozyme,1.5,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,119,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,24,7,Increase,Above,22,2,2,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,SOD,1.2,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,121,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,27,10,Increase,Above,25,5,5,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,SOD,1,Same,NA,NA,N,China ,Aquaculture,Not stated,5,6,122,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,25,10,Increase,Above,24,6,6,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,Catalase,2,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,306,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,28,13,Increase,Above,27,9,9,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,Catalase,2.1,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,307,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,25,10,Increase,Above,24,6,6,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,GSH ,1.2,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,308,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,gss,Unknown,gss,GSS,ligase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,28,13,Increase,Above,27,9,9,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,GSH ,2,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,309,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,gss,Unknown,gss,GSS,ligase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,25,10,Increase,Above,24,6,6,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,GSH-Px,2,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,310,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,gss,Unknown,gss,GSS,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,28,13,Increase,Above,27,9,9,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,GSH-Px,1.2,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,311,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,gss,Unknown,gss,GSS,Unknown,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,25,10,Increase,Above,24,6,6,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,LPO,1.1,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,324,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,lpo,Unknown,lpo,LPO,Unknown,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,28,13,Increase,Above,27,9,9,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,LPO,1.1,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,325,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,lpo,Unknown,lpo,LPO,Unknown,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,25,10,Increase,Above,24,6,6,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,SOD,1.2,Increase,NA,NA,NA,China ,Aquaculture,50,3,17,326,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Acipenser baerii,F + B,Temperate,Acipenser baerii,Acipenseridae,1,19,18,Wide,Not stated,Not stated,Not stated,Exp,15,Within,28,13,Increase,Above,27,9,9,12 days (7 days to reach final temperature),Cellular ,Kits,Blood plasma,Protein,SOD,1,Same,NA,NA,NA,China ,Aquaculture,50,3,17,327,Chronic,NA,"Yang, S., Yang, X., Li, Y., Li, D., Gong, Q., Huang, X., Wu, J., Huang, A., Kong, F., Han, X. and Zeng, X., 2021. The multilevel responses of Acipenser baerii and its hybrids (A. baerii?× A. schrenckii?) to chronic heat stress. Aquaculture, 541, p.736773.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Atlantic salmon (Salmo salar L.),M + F + B,Temperate,Salmo salar,Salmonidae,2,9,7,Narrow,not stated ,Not stated,Not stated,Exp,12,Above,20,8,Increase,Above,18,11,11,4 weeks,Cellular,,plasma,Protein,Hemolytic activity of complement,1,Same,NA,NA,N,Canada ,Aquaculture,6,not stated,29,458,Chronic,NA,"Zanuzzo, F.S., Beemelmanns, A., Hall, J.R., Rise, M.L. and Gamperl, A.K., 2020. The innate immune response of Atlantic salmon (Salmo salar) is not negatively affected by high temperature and moderate hypoxia. Frontiers in immunology, 11, p.1009.",complement,Unknown,c9,Unknown,c9,C9,Unknown,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Atlantic salmon (Salmo salar L.),M + F + B,Temperate,Salmo salar,Salmonidae,2,9,7,Narrow,not stated ,Not stated,Not stated,Exp,12,Above,20,8,Increase,Above,18,11,11,4 weeks,Cellular,,plasma,Protein,Lysozyme,1.2,Increase,NA,NA,NA,Canada ,Aquaculture,6,not stated,29,465,Chronic,NA,"Zanuzzo, F.S., Beemelmanns, A., Hall, J.R., Rise, M.L. and Gamperl, A.K., 2020. The innate immune response of Atlantic salmon (Salmo salar) is not negatively affected by high temperature and moderate hypoxia. Frontiers in immunology, 11, p.1009.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019,lt Chinese sturgeon (Acipenser sinensis),M + F + B,Temperate,Acipenser sinensis,Acipenseridae,15.6,23.5,7.9,Narrow,subadult ,Juvenile,Not stated,Exp ,18,Within,24,6,Increase,Above,8.4,0.5,0.5,90 days ,Cellular ,Turbidometric,Blood,Protein,Lysozyme,0.9,Decrease,Chemical,ammonia nitrogen conditions,N,China ,Aquaculture,4,3,46,737,Chronic,NA,"Zhang, H., Ni, Q., Zhang, Y., Wu, F., Liu, H., Long, L. and Guan, C., 2019. Effects of temperature on growth, hematology, and immune responses of subadult Chinese sturgeon (Acipenser sinensis Gray 1835) under different ammonia nitrogen conditions in recirculating aquaculture system. Journal of Applied Ichthyology, 35(1), pp.313-322.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019,lt Chinese sturgeon (Acipenser sinensis),M + F + B,Temperate,Acipenser sinensis,Acipenseridae,15.6,23.5,7.9,Narrow,subadult ,Juvenile,Not stated,Exp ,18,Within,24,6,Increase,Above,8.4,0.5,0.5,90 days ,Cellular ,,Blood,Protein,SOD,1.1,Increase,Chemical,ammonia nitrogen conditions,N,China ,Aquaculture,4,3,46,739,Chronic,NA,"Zhang, H., Ni, Q., Zhang, Y., Wu, F., Liu, H., Long, L. and Guan, C., 2019. Effects of temperature on growth, hematology, and immune responses of subadult Chinese sturgeon (Acipenser sinensis Gray 1835) under different ammonia nitrogen conditions in recirculating aquaculture system. Journal of Applied Ichthyology, 35(1), pp.313-322.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Zebrafish ,F,Tropical,Danio rerio,Danionidae,18,24,6,Narrow,10 weeks,Adult,Equal ratio,Exp ,26,Above,32,6,Increase,Above,14,8,8,7 days ,Cellular ,Spectrophotometer,Spleen,Protein,Catalase,2.5,Increase,Other,Cadium  5ug/ml,N,China ,Aquaculture,20,4,53,801,Chronic,NA,"Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S. and Zheng, J.L., 2018. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & Shellfish Immunology, 72, pp.1-8.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2018,Zebrafish ,F,Tropical,Danio rerio,Danionidae,18,24,6,Narrow,10 weeks,Adult,Equal ratio,Exp ,26,Above,32,6,Increase,Above,14,8,8,7 days ,Cellular ,Spectrophotometer,Spleen,Protein,Catalase,0.8,Decrease,NA,NA,NA,China ,Aquaculture,20,4,53,800,Chronic,NA,"Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S. and Zheng, J.L., 2018. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & Shellfish Immunology, 72, pp.1-8.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 15/11/22,2018,Zebrafish ,F,Tropical,Danio rerio,Danionidae,18,24,6,Narrow,10 weeks,Adult,Equal ratio,Exp ,26,Above,32,6,Increase,Above,14,8,8,7 days ,Cellular ,Spectrophotometer,Spleen,Protein,Cu/Zn-SOD,2,Increase,Other,Cadium  5ug/ml,N,China ,Aquaculture,20,4,53,805,Chronic,NA,"Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S. and Zheng, J.L., 2018. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & Shellfish Immunology, 72, pp.1-8.",,Unknown,sod1,Unknown,sod1,SOD1,oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Zebrafish ,F,Tropical,Danio rerio,Danionidae,18,24,6,Narrow,10 weeks,Adult,Equal ratio,Exp ,26,Above,32,6,Increase,Above,14,8,8,7 days ,Cellular ,Spectrophotometer,Spleen,Protein,Cu/Zn-SOD,0.5,Decrease,NA,NA,NA,China ,Aquaculture,20,4,53,804,Chronic,NA,"Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S. and Zheng, J.L., 2018. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & Shellfish Immunology, 72, pp.1-8.",,Unknown,sod1,Unknown,sod1,SOD1,oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 15/11/22,2018,Zebrafish ,F,Tropical,Danio rerio,Danionidae,18,24,6,Narrow,10 weeks,Adult,Equal ratio,Exp ,26,Above,32,6,Increase,Above,14,8,8,7 days ,Cellular ,Assay kit,Spleen,Protein,iNOS,1,Same,Other,Cadium  5ug/ml,N,China ,Aquaculture,20,4,53,817,Chronic,NA,"Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S. and Zheng, J.L., 2018. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & Shellfish Immunology, 72, pp.1-8.",,Unknown,Unknown,nos1apa,nos1apa,NOS2,Unknown,1,1,1,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0
Yes 15/11/22,2018,Zebrafish ,F,Tropical,Danio rerio,Danionidae,18,24,6,Narrow,10 weeks,Adult,Equal ratio,Exp ,26,Above,32,6,Increase,Above,14,8,8,7 days ,Cellular ,Assay kit,Spleen,Protein,iNOS,1,Same,NA,NA,NA,China ,Aquaculture,20,4,53,816,Chronic,NA,"Zhao, S.J., Guo, S.N., Zhu, Q.L., Yuan, S.S. and Zheng, J.L., 2018. Heat-induced oxidative stress and inflammation involve in cadmium pollution history in the spleen of zebrafish. Fish & Shellfish Immunology, 72, pp.1-8.",,Unknown,Unknown,nos1apa,nos1apa,NOS2,Unknown,1,1,1,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0
Yes 10/11/22,2020,Piaractus mesopotamicus ,F,Subtropical,Piaractus mesopotamicus,Serrasalmidae,NS,NS,NS,NA,Juvenile ,Juvenile,Not stated,Exp,27,Below,22.5,-4.5,Decrease,Below,NA,NA,NA,72 hour,Cellular ,red cell lysis assay,,Protein,Hemolytic activity of complement,2,Increase,Chemical,Vitamin E but using control fed fish in every case so not a factor,N,Brazil ,Aquaculture,8,not stated,28,451,Chronic,NA,"Barbosa, L.M.G., Moraes, G., de Freitas Anibal, F. and Marzocchi-Machado, C.M., 2020. Effect of environmental thermal fluctuations on innate immune responses in pacu Piaractus mesopotamicus juveniles. Aquaculture Reports, 17, p.100303.",complement,Unknown,c9,Unknown,c9,C9,Unknown,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Piaractus mesopotamicus ,F,Subtropical,Piaractus mesopotamicus,Serrasalmidae,NS,NS,NS,NA,Juvenile ,Juvenile,Not stated,Exp,27,Below,22.5,-4.5,Decrease,Below,NA,NA,NA,72 hour,Cellular ,turbidimetric assay,,Protein,Lysozyme,0.9,Decrease,Chemical,Vitamin E but using control fed fish in every case so not a factor,N,Brazil,Aquaculture,8,not stated,28,452,Chronic,NA,"Barbosa, L.M.G., Moraes, G., de Freitas Anibal, F. and Marzocchi-Machado, C.M., 2020. Effect of environmental thermal fluctuations on innate immune responses in pacu Piaractus mesopotamicus juveniles. Aquaculture Reports, 17, p.100303.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,20,-5,Decrease,Below,-4.4,-9.1,-4.4,3 hours ,Cellular ,Functional assay,Liver,Protein,Catalase,1.5,Increase,Other,Control diet,N,China ,Aquaculture,6,3,72,1014,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,15,-10,Decrease,Below,-9.4,-14.1,-9.4,3 hours ,Cellular ,Functional assay,Liver,Protein,Catalase,1.5,Increase,Other,Control diet,N,China ,Aquaculture,6,3,72,1015,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,10,-15,Decrease,Below,-14.4,-19.1,-14.4,3 hours ,Cellular ,Functional assay,Liver,Protein,Catalase,0.8,Decrease,Other,Control diet,N,China ,Aquaculture,6,3,72,1016,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,20,-5,Decrease,Below,-4.4,-9.1,-4.4,3 hours ,Cellular ,Functional assay,Liver,Protein,Catalase,1.25,Increase,Other,FABP10 additive,N,China ,Aquaculture,6,3,72,1017,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,15,-10,Decrease,Below,-9.4,-14.1,-9.4,3 hours ,Cellular ,Functional assay,Liver,Protein,Catalase,1,Same,Other,FABP10 additive,N,China ,Aquaculture,6,3,72,1018,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,10,-15,Decrease,Below,-14.4,-19.1,-14.4,3 hours ,Cellular ,Functional assay,Liver,Protein,Catalase,0.8,Decrease,Other,FABP10 additive,N,China ,Aquaculture,6,3,72,1019,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,20,-5,Decrease,Below,-4.4,-9.1,-4.4,3 hours ,Cellular ,Functional assay,Liver,Protein,SOD,0.5,Decrease,Other,Control diet,N,China ,Aquaculture,6,3,72,1026,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,15,-10,Decrease,Below,-9.4,-14.1,-9.4,3 hours ,Cellular ,Functional assay,Liver,Protein,SOD,0.7,Decrease,Other,Control diet,N,China ,Aquaculture,6,3,72,1027,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,10,-15,Decrease,Below,-14.4,-19.1,-14.4,3 hours ,Cellular ,Functional assay,Liver,Protein,SOD,0.3,Decrease,Other,Control diet,N,China ,Aquaculture,6,3,72,1028,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,20,-5,Decrease,Below,-4.4,-9.1,-4.4,3 hours ,Cellular ,Functional assay,Liver,Protein,SOD,1.1,Increase,Other,FABP10 additive,N,China ,Aquaculture,6,3,72,1029,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,15,-10,Decrease,Below,-9.4,-14.1,-9.4,3 hours ,Cellular ,Functional assay,Liver,Protein,SOD,1.1,Increase,Other,FABP10 additive,N,China ,Aquaculture,6,3,72,1030,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 17/11/22,2014,Orange-spotted grouper (Epinephelus coioides),M + B,Subtropical,Epinephelus coioides,Serranidae,24.4,29.1,4.7,Narrow,weight 7.76g,Juvenile,Not stated,Exp ,25,Within,10,-15,Decrease,Below,-14.4,-19.1,-14.4,3 hours ,Cellular ,Functional assay,Liver,Protein,SOD,1,Same,Other,FABP10 additive,N,China ,Aquaculture,6,3,72,1031,Acute,NA,"Luo, S.W., Cai, L., Liu, Y. and Wang, W.N., 2014. Functional analysis of a dietary recombinant Fatty acid binding protein 10 (FABP10) on the Epinephelus coioides in response to acute low temperature challenge. Fish & shellfish immunology, 36(2), pp.475-484.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Salmo caspius ,M + F + B,Subtropical,Salmo caspius,Salmonidae,NS,NS,NS,NA,Juveniles ,Juvenile,Not stated,Exp ,8,Below,5,-3,Decrease,Below,NA,NA,NA,24hours ,Cellular ,Bradford based method,serum,Protein,IgM-antigen specific,0.6,Decrease,NA,NA,N,Iran ,Aquaculture,10,3,34,565,Acute,NA,"Rezakhani, S., Mohammadizadeh, F., Khara, H., Bahri, A.H. and Ahmadnezhad, M., 2020. Immunological, hematological, and histological responses in blood, spleen and gill of Salmo caspius juveniles exposed in different water temperatures. Iranian Journal of Fisheries Sciences, 19(6), pp.2925-2942.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Salmo caspius ,M + F + B,Subtropical,Salmo caspius,Salmonidae,NS,NS,NS,NA,Juveniles ,Juvenile,Not stated,Exp ,8,Below,5,-3,Decrease,Below,NA,NA,NA,24hours ,Cellular ,Turbidimetric assay,serum,Protein,Lysozyme,0.5,Decrease,NA,NA,N,Iran ,Aquaculture,10,3,34,567,Acute,NA,"Rezakhani, S., Mohammadizadeh, F., Khara, H., Bahri, A.H. and Ahmadnezhad, M., 2020. Immunological, hematological, and histological responses in blood, spleen and gill of Salmo caspius juveniles exposed in different water temperatures. Iranian Journal of Fisheries Sciences, 19(6), pp.2925-2942.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Channa punctata,F + B,Tropical,Channa punctata,Channidae,22,28,6,Narrow,Not stated,Not stated,Not stated,Exp ,25,Within,10,-15,Decrease,Below,-12,-18,-12,7 days ,Cellular ,ELISA,Liver,Protein,HSP70,1,Same,NA,NA,NA,India,Aquaculture,5,3,22,397,Chronic,NA,"Singh, S.P., Ahmad, T., Sharma, J. and Chakrabarti, R., 2021. Effect of temperature on food consumption, immune system, antioxidant enzymes, and heat shock protein 70 of Channa punctata (Bloch, 1793). Fish Physiology and Biochemistry, 47(1), pp.79-91.",,Unknown,hsp70.1,Unknown,hsp70.1,HSPA4,Hsp70 family chaperone,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2019,Yellow drum (Nibea albiflora),M,Temperate,Nibea albiflora,Sciaenidae,16.8,24.7,7.9,Narrow,6 months ,Not stated,Not stated,Exp ,16,Below,8,-8,Decrease,Below,-8.8,-16.7,-8.8,"14 days, time course of response; taken day 14 as a snapshot",Cellular,kits,Liver,Protein,Catalase,0.6,Decrease,Other,Starvation but data from fed control fish in all cases so diet not a counfounding factor,N,China,Aquaculture,4,2,37,596,Chronic,NA,"Song, H., Xu, D., Tian, L., Chen, R., Wang, L., Tan, P. and You, Q., 2019. Overwinter mortality in yellow drum (Nibea albiflora): insights from growth and immune responses to cold and starvation stress. Fish & Shellfish Immunology, 92, pp.341-347.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 11/11/22,2019,Yellow drum (Nibea albiflora),M,Temperate,Nibea albiflora,Sciaenidae,16.8,24.7,7.9,Narrow,6 months ,Not stated,Not stated,Exp ,16,Below,8,-8,Decrease,Below,-8.8,-16.7,-8.8,"14 days, time course of response; taken day 14 as a snapshot",Cellular,kits,Liver,Protein,SOD,0.8,Decrease,Other,Starvation but data from fed control fish in all cases so diet not a counfounding factor,N,China,Aquaculture,4,2,37,601,Chronic,NA,"Song, H., Xu, D., Tian, L., Chen, R., Wang, L., Tan, P. and You, Q., 2019. Overwinter mortality in yellow drum (Nibea albiflora): insights from growth and immune responses to cold and starvation stress. Fish & Shellfish Immunology, 92, pp.341-347.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,pufferfish (Takifugu fascitus),Not stated,Not stated,Takifugu fasciatus,Tetraodontidae,NS,NS,NS,NA,Not stated ,Not stated,Not stated,Exp,25,Below,13,-12,Decrease,Below,NA,NA,NA,90 hours ,Cellular,ELISA,Liver ,Protein,IgM-antigen specific,0.5,Decrease,NA,NA,NA,China ,Aquaculture,9,3,20,359,Chronic,NA,"Wen, X., Chu, P., Xu, J., Wei, X., Fu, D., Wang, T. and Yin, S., 2021. Combined effects of low temperature and salinity on the immune response, antioxidant capacity and lipid metabolism in the pufferfish (Takifugu fasciatus). Aquaculture, 531, p.735866.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,pufferfish (Takifugu fascitus),Not stated,Not stated,Takifugu fasciatus,Tetraodontidae,NS,NS,NS,NA,Not stated ,Not stated,Not stated,Exp,25,Below,17,-8,Decrease,Below,NA,NA,NA,96 hours ,Cellular,ELISA,Liver ,Protein,IgM-antigen specific,0.6,Decrease,NA,NA,NA,China ,Aquaculture,9,3,20,360,Chronic,NA,"Wen, X., Chu, P., Xu, J., Wei, X., Fu, D., Wang, T. and Yin, S., 2021. Combined effects of low temperature and salinity on the immune response, antioxidant capacity and lipid metabolism in the pufferfish (Takifugu fasciatus). Aquaculture, 531, p.735866.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,pufferfish (Takifugu fascitus),Not stated,Not stated,Takifugu fasciatus,Tetraodontidae,NS,NS,NS,NA,Not stated ,Not stated,Not stated,Exp,25,Below,21,-4,Decrease,Below,NA,NA,NA,96 hours ,Cellular,ELISA,Liver ,Protein,IgM-antigen specific,0.4,Decrease,NA,NA,NA,China ,Aquaculture,9,3,20,361,Chronic,NA,"Wen, X., Chu, P., Xu, J., Wei, X., Fu, D., Wang, T. and Yin, S., 2021. Combined effects of low temperature and salinity on the immune response, antioxidant capacity and lipid metabolism in the pufferfish (Takifugu fasciatus). Aquaculture, 531, p.735866.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,pufferfish (Takifugu fascitus),Not stated,Not stated,Takifugu fasciatus,Tetraodontidae,NS,NS,NS,NA,Not stated ,Not stated,Not stated,Exp,25,Below,13,-12,Decrease,Below,NA,NA,NA,96 hours ,Cellular,Turbidometric,Liver ,Protein,Lysozyme,0.5,Decrease,NA,NA,NA,China ,Aquaculture,9,3,20,368,Chronic,NA,"Wen, X., Chu, P., Xu, J., Wei, X., Fu, D., Wang, T. and Yin, S., 2021. Combined effects of low temperature and salinity on the immune response, antioxidant capacity and lipid metabolism in the pufferfish (Takifugu fasciatus). Aquaculture, 531, p.735866.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,pufferfish (Takifugu fascitus),Not stated,Not stated,Takifugu fasciatus,Tetraodontidae,NS,NS,NS,NA,Not stated ,Not stated,Not stated,Exp,25,Below,17,-8,Decrease,Below,NA,NA,NA,96 hours ,Cellular,Turbidometric,Liver ,Protein,Lysozyme,0.6,Decrease,NA,NA,NA,China ,Aquaculture,9,3,20,369,Chronic,NA,"Wen, X., Chu, P., Xu, J., Wei, X., Fu, D., Wang, T. and Yin, S., 2021. Combined effects of low temperature and salinity on the immune response, antioxidant capacity and lipid metabolism in the pufferfish (Takifugu fasciatus). Aquaculture, 531, p.735866.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,pufferfish (Takifugu fascitus),Not stated,Not stated,Takifugu fasciatus,Tetraodontidae,NS,NS,NS,NA,Not stated ,Not stated,Not stated,Exp,25,Below,21,-4,Decrease,Below,NA,NA,NA,96 hours ,Cellular,Turbidometric,Liver ,Protein,Lysozyme,1.3,Increase,NA,NA,NA,China ,Aquaculture,9,3,20,370,Chronic,NA,"Wen, X., Chu, P., Xu, J., Wei, X., Fu, D., Wang, T. and Yin, S., 2021. Combined effects of low temperature and salinity on the immune response, antioxidant capacity and lipid metabolism in the pufferfish (Takifugu fasciatus). Aquaculture, 531, p.735866.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019,lt Chinese sturgeon (Acipenser sinensis),M + F + B,Temperate,Acipenser sinensis,Acipenseridae,15.6,23.5,7.9,Narrow,subadult ,Juvenile,Not stated,Exp ,18,Within,12,-6,Decrease,Below,-3.6,-11.5,-3.6,90 days ,Cellular ,Turbidometric,Blood,Protein,Lysozyme,1,Same,Chemical,ammonia nitrogen conditions,N,China ,Aquaculture,4,3,46,736,Chronic,NA,"Zhang, H., Ni, Q., Zhang, Y., Wu, F., Liu, H., Long, L. and Guan, C., 2019. Effects of temperature on growth, hematology, and immune responses of subadult Chinese sturgeon (Acipenser sinensis Gray 1835) under different ammonia nitrogen conditions in recirculating aquaculture system. Journal of Applied Ichthyology, 35(1), pp.313-322.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 14/11/22,2019,lt Chinese sturgeon (Acipenser sinensis),M + F + B,Temperate,Acipenser sinensis,Acipenseridae,15.6,23.5,7.9,Narrow,subadult ,Juvenile,Not stated,Exp ,18,Within,12,-6,Decrease,Below,-3.6,-11.5,-3.6,90 days ,Cellular ,,Blood,Protein,SOD,1,Same,Chemical,ammonia nitrogen conditions,N,China ,Aquaculture,4,3,46,738,Chronic,NA,"Zhang, H., Ni, Q., Zhang, Y., Wu, F., Liu, H., Long, L. and Guan, C., 2019. Effects of temperature on growth, hematology, and immune responses of subadult Chinese sturgeon (Acipenser sinensis Gray 1835) under different ammonia nitrogen conditions in recirculating aquaculture system. Journal of Applied Ichthyology, 35(1), pp.313-322.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Salmo caspius ,M + F + B,Subtropical,Salmo caspius,Salmonidae,NS,NS,NS,NA,Juveniles ,Juvenile,Not stated,Exp ,8,Below,20,12,Increase,Below,NA,NA,NA,24hours ,Cellular ,Bradford based method,serum,Protein,IgM-antigen specific,0.8,Decrease,NA,NA,N,Iran ,Aquaculture,10,3,34,566,Acute,NA,"Rezakhani, S., Mohammadizadeh, F., Khara, H., Bahri, A.H. and Ahmadnezhad, M., 2020. Immunological, hematological, and histological responses in blood, spleen and gill of Salmo caspius juveniles exposed in different water temperatures. Iranian Journal of Fisheries Sciences, 19(6), pp.2925-2942.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 11/11/22,2020,Salmo caspius ,M + F + B,Subtropical,Salmo caspius,Salmonidae,NS,NS,NS,NA,Juveniles ,Juvenile,Not stated,Exp ,8,Below,20,12,Increase,Below,NA,NA,NA,24hours ,Cellular ,Turbidimetric assay,serum,Protein,Lysozyme,1,Same,NA,NA,N,Iran ,Aquaculture,10,3,34,568,Acute,NA,"Rezakhani, S., Mohammadizadeh, F., Khara, H., Bahri, A.H. and Ahmadnezhad, M., 2020. Immunological, hematological, and histological responses in blood, spleen and gill of Salmo caspius juveniles exposed in different water temperatures. Iranian Journal of Fisheries Sciences, 19(6), pp.2925-2942.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,23,5,Increase,Within,20,-12,-12,60 days ,Cellular ,turbidimetric assay,Serum,Protein,C3,0.9,Decrease,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,922,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,28,10,Increase,Within,25,-7,-7,60 days ,Cellular ,turbidimetric assay,Serum,Protein,C3,1.3,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,923,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,23,5,Increase,Within,20,-12,-12,60 days ,Cellular ,turbidimetric assay,Serum,Protein,IgM-antigen specific,1.5,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,930,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,28,10,Increase,Within,25,-7,-7,60 days ,Cellular ,turbidimetric assay,Serum,Protein,IgM-antigen specific,1.5,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,931,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,23,5,Increase,Within,20,-12,-12,60 days ,Cellular ,turbidimetric assay,Serum,Protein,IgM-antigen specific,1.3,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,932,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,28,10,Increase,Within,25,-7,-7,60 days ,Cellular ,turbidimetric assay,Serum,Protein,IgM-antigen specific,1.4,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,933,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,23,5,Increase,Within,20,-12,-12,60 days ,Cellular ,blank contrast method,Liver,Protein,Lysozyme,1.2,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,934,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,28,10,Increase,Within,25,-7,-7,60 days ,Cellular ,blank contrast method,Liver,Protein,Lysozyme,1.25,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,935,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,23,5,Increase,Within,20,-12,-12,60 days ,Cellular ,blank contrast method,,Protein,Lysozyme,1.5,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,936,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,28,10,Increase,Within,25,-7,-7,60 days ,Cellular ,blank contrast method,,Protein,Lysozyme,1.6,Increase,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,937,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,23,5,Increase,Within,20,-12,-12,60 days ,Cellular ,xanthine oxidase method,Liver,Protein,SOD,0.06,Decrease,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,938,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2015,Mirror carp (Cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Juvenile ,Juvenile,Not stated,Exp ,18,Within,28,10,Increase,Within,25,-7,-7,60 days ,Cellular ,xanthine oxidase method,Liver,Protein,SOD,0.8,Decrease,Other,Protein diet - comparing low protein groups in every case,N,China ,Aquaculture,6,5,66,939,Chronic,NA,"Huang, J.F., Xu, Q.Y. and Chang, Y.M., 2015. Effects of temperature and dietary protein on gene expression of Hsp70 and Wap65 and immunity of juvenile mirror carp (C yprinus carpio). Aquaculture Research, 46(11), pp.2776-2788.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2016,goldfish (Carassius auratus),F + B,Subtropical,Carassius auratus,Cyprinidae,0,41,41,Wide,12cm,Not stated,Not stated,Exp ,22,Within,30,8,Increase,Within,30,-11,-11,>12 hours,Cellular ,ELISA,Liver,Protein,Catalase,1.8,Increase,Chemical x Other,Melatonin but comparing controls x Wavelength,N,Korea ,Aquaculture,27,not stated,64,915,Acute,NA,"Jung, S.J., Choi, Y.J., Kim, N.N., Choi, J.Y., Kim, B.S. and Choi, C.Y., 2016. Effects of melatonin injection or green-wavelength LED light on the antioxidant system in goldfish (Carassius auratus) during thermal stress. Fish & Shellfish Immunology, 52, pp.157-166.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 16/11/22,2016,goldfish (Carassius auratus),F + B,Subtropical,Carassius auratus,Cyprinidae,0,41,41,Wide,12cm,Not stated,Not stated,Exp ,22,Within,30,8,Increase,Within,30,-11,-11,>12 hours,Cellular ,turbidimetric assay,plasma,Protein,Lysozyme,1,Same,Chemical x Other,Melatonin but comparing controls x Wavelength,N,Korea ,Aquaculture,27,not stated,64,917,Acute,NA,"Jung, S.J., Choi, Y.J., Kim, N.N., Choi, J.Y., Kim, B.S. and Choi, C.Y., 2016. Effects of melatonin injection or green-wavelength LED light on the antioxidant system in goldfish (Carassius auratus) during thermal stress. Fish & Shellfish Immunology, 52, pp.157-166.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2016,goldfish (Carassius auratus),F + B,Subtropical,Carassius auratus,Cyprinidae,0,41,41,Wide,12cm,Not stated,Not stated,Exp ,22,Within,30,8,Increase,Within,30,-11,-11,>12 hours,Cellular ,ELISA,Liver,Protein,SOD,2,Increase,Chemical x Other,Melatonin but comparing controls x Wavelength,N,Korea ,Aquaculture,27,not stated,64,919,Acute,NA,"Jung, S.J., Choi, Y.J., Kim, N.N., Choi, J.Y., Kim, B.S. and Choi, C.Y., 2016. Effects of melatonin injection or green-wavelength LED light on the antioxidant system in goldfish (Carassius auratus) during thermal stress. Fish & Shellfish Immunology, 52, pp.157-166.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 16/11/22,2016,Goldfish (Carassius auratus),F + B,Subtropical,Carassius auratus,Cyprinidae,0,41,41,Wide,15g,Not stated,Not stated,Exp ,22,Within,30,8,Increase,Within,30,-11,-11,36 hours ,Cellular ,ELISA,plasma,Protein,IgM-antigen specific,0.8,Decrease,Other,Wavelength light,N,Korea ,Aquaculture,30,not stated,63,913,Acute,NA,"Jung, S.J., Kim, N.N., Choi, Y.J., Choi, J.Y., Choi, Y.U., Heo, Y.S. and Choi, C.Y., 2016. Effects of melatonin and green-wavelength LED light on the physiological stress and immunity of goldfish, Carassius auratus, exposed to high water temperature. Fish physiology and biochemistry, 42(5), pp.1335-1346.",,Unknown,Unknown,Unknown,IgM-antigen specific,IGHM,Unknown,0,0,0,0,0,0,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,21,4,Increase,Within,19,-1,-1,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,ALP activity,1,Same,NA,NA,N,China ,Aquaculture,Not stated,5,6,111,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",Protein - alkaline phosphatase,,alpl,Unknown,alpl,ALPL,phosphatase,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,21,4,Increase,Within,19,-1,-1,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,Catalase,1.2,Increase,NA,NA,N,China ,Aquaculture,Not stated,5,6,114,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,cat,Unknown,cat,CAT,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,1,1,0,0,0,1,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,21,4,Increase,Within,19,-1,-1,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,Lysozyme,1,Same,NA,NA,N,China ,Aquaculture,Not stated,5,6,117,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,lyz,Unknown,lyz,LYZ,glycosidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2021,Crucian Carp,F + B,Temperate,Carassius carassius,Cyprinidae,2,22,20,Wide,Three month,Not stated,Not stated,Exp,17,Within,21,4,Increase,Within,19,-1,-1,3C increased every day,cellular ,colouremetric ,Mucus ,Protein,SOD,1,Same,NA,NA,N,China ,Aquaculture,Not stated,5,6,120,Chronic,NA,"Wang, B., Ma, G., Liu, Y., Wang, Y., Du, X., Shi, Q. and Mao, H., 2021. Effects of Different Temperatures on the Antibacterial, Immune and Growth Performance of Crucian Carp Epidermal Mucus. Fishes, 6(4), p.66.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Koi (cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Not stated,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Within,29,-3,-3,24 hours ,Cellular ,Kits,plasma,Protein,C3,2,Increase,NA,NA,NA,China ,Aquaculture,9,3,27,446,Acute,NA,"Yu, H., Zhang, C., Xing, W., Li, T., Xu, G., Ma, Z., Jiang, N. and Luo, L., 2020. Comparative study on the non-specific immune response and hsp70 gene expression among three strains of koi (Cyprinus carpio) under acute heat stress. Aquaculture Reports, 18, p.100461.",,Unknown,c3a.1,Unknown,c3a.1,C3,Unknown,0,0,0,1,1,0,0,0,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Koi (cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Not stated,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Within,29,-3,-3,24 hours ,Cellular ,MPO activity,plasma,Protein,MPO,2,Increase,NA,NA,NA,China ,Aquaculture,9,3,27,448,Acute,NA,"Yu, H., Zhang, C., Xing, W., Li, T., Xu, G., Ma, Z., Jiang, N. and Luo, L., 2020. Comparative study on the non-specific immune response and hsp70 gene expression among three strains of koi (Cyprinus carpio) under acute heat stress. Aquaculture Reports, 18, p.100461.",,Unknown,mpx,Unknown,mpx,MPO,peroxidase,0,0,0,1,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0
Yes 10/11/22,2020,Koi (cyprinus carpio),F + B,Subtropical,Cyprinus carpio,Cyprinidae,3,35,32,Wide,Not stated,Not stated,Not stated,Exp ,25,Within,32,7,Increase,Within,29,-3,-3,24 hours ,Cellular ,SOD activity assau,plasma,Protein,SOD,1,Same,NA,NA,NA,China ,Aquaculture,9,3,27,450,Acute,NA,"Yu, H., Zhang, C., Xing, W., Li, T., Xu, G., Ma, Z., Jiang, N. and Luo, L., 2020. Comparative study on the non-specific immune response and hsp70 gene expression among three strains of koi (Cyprinus carpio) under acute heat stress. Aquaculture Reports, 18, p.100461.",,Unknown,sod1,Unknown,sod1,SOD1,Oxidoreductase,1,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,1,0,0,1,1,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,0,0,1,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,0,1,0,1,0,0,0,0,0,0,0,0,0,0,0,0
,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,,